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Why Immunosuppression Is Not Necessary For Implantation of Our Stem Cell Transplants

Immunosuppression – to use it or not to use it with stem cell transplantation – has been a subject of heated arguments among physicians practicing this field of medicine for the past 20+ years.

European physicians have not used immunosuppression after cell transplantation, even of cells of animal fetal origin,  because they observed in their clinical practice that 

• allergic reactions were infrequent (incidence less than 5%), 
  
  
• anaphylactic shock was rare, and 
  
  
• allergic reactions never caused death of a patient(!),

but they used a premedication by antihistamins and cortison.

This was established beyond any legal doubt by the investigation ordered by German Supreme Court in the case    # 1 BvR 420/97. 

Since in Europe ~ 5 million patients have been treated by various forms of cell transplantation, mostly of animal fetal origin, and none of them received  immunosuppression after implantation, there was hardly any need to search for scientific proofs. “Res ipsa loquitur! (Facts speak for themselves!)”

There are many published medical reports on hundreds of patients showing that changes of laboratory parameters of the immune system function before and after stem cell transplantation are minimal & statistically not significant. 

This confirms the absence of any noticeable clinical immune reactions after stem cell transplantation providing stem cell transplants were prepared properly, such as by our method. 

(biocell@stem-cell-transplantation.com)

U.S. physicians are adamant that long term immunosuppression must be used after stem cell transplantation although the total U.S. experience amounts to less than 3,000 patients (and most of these patients had neurotransplantation where immunosuppression is truly unnecessary, as it is commonly known that implanted fetal brain tissue is non-antigenic).

The problem lies with immunologists. 

The European fathers of immunology could be convinced already in 60-ies to personally observe the patient treatments with live cell xeno-transplants and recognize - to their great surprise - that the recipient patients not only did not die of anaphylactic shock, on the contrary they exhibited no clinically apparent immune reactions whatsoever. 

U.S. immunologists have never permitted any stem cell transplantation to be done without immunosuppression via various political channels, hospital committees, medical associations, medical malpractice insurance companies, and 

thus - outside of clinical trials carried out in the U.S. with our cell transplants in 1993 and 1995 - no U.S. physician has had an opportunity to 'learn the truth'.

Until we will learn what life is, and many philosophers believe that it will never happen, and thus cannot explain many aspects of the function of living bodies, we have to be satisfied with the fact that implantation of 'state-of-art' stem cell transplants does not cause untoward immune or allergic reactions. 

The use of high dose immunosuppression has been one of the main reasons why the success rate of cell transplantation has been so poor in the U.S, as compared with Europe. 

Long term immunosuppression is not only dangerous to the patients, it is also detrimental to the stem cell transplants, because these are very young cells, enormously sensitive to any toxin, and immunosuppressants are indeed highly toxic! 

Since U.S. medicine carries a 'big stick' of pharmaceutical industry, it is very important to convince U.S. physicians to participate in the clinical use of stem cell transplantation in other countries, so that they can 'see the light' for themselves.

Such controversy, without scientific merit, skillfully used against cell transplantation as a therapeutic method by pharmaceutical industry, stimulated us to develop a method of preparation of stem cell transplants, the implantation of which does not cause any immune reactions at all! 

The controversy should have ended when we presented the existence of such method to the U.S. FDA in 1997, but the U.S. medicine continues to demand the use of immunosuppression. 

In our opinion this will jeopardize the outcome of stem cell transplantation in the U.S. 

The negative attitude of pharmaceutical industry toward cell transplantation make no sense: throughout its 75  years’ long history stem cell transplantation has been used predominantly 

• for patients with serious diseases who have not responded, or no longer responded, to the usual, or standard, medical treatment, or 
  
  
• for those who suffered from diseases without any known treatment,

in other words stem cell transplantation has not replaced the orthodox medical therapies, which bring profits to the pharmaceutical industry. 

So there has been no need to look at stem cell transplantation as competition.

Such repression has nearly halted the research in (stem) cell therapy in Germany during the last 15 years. 

Russian Federation and other countries of the former U.S.S.R., the other leader in stem cell transplantation field, ever since it became a part of 'free world', has been under the influence of pharmaceutical lobby, and does not 'waste money' on medical research in stem cell transplantation anymore. 

Just because the futurologists of pharmaceutical industry cannot forecast immediate hefty profits from stem cell transplantation, there is no reason to force this most promising and valuable therapy into oblivion.

The above can be studied in a textbook of E. Michael Molnar, M.D. "Stem Cell Transplantation, a Textbook of Stem Cell Xeno-Transplantation", published by Medical And Engineering Publishers, Inc., Washington, D.C., in February 2006, the first textbook for medical profession and students in the world about this subject. Click on www.mepublishers.com

(biocell@stem-cell-transplantation.com)

Our know-how, based on 25+ years of experience, permits us to offer you in this web site  

• free advice about the usefulness of stem cell transplantation as a therapy of illness(es) that you, or your loved ones, suffer from, which you could get nowhere else on the Web, (click on "How to get SCT treatment" on the MENU bar, if you wish to learn more about this free service) 
  
  (Please, beware that stem cell transplantation is not a 'wonder' treatment for all diseases known to mankind, and so it may be of no use in your particular case.)

as well as a possibility to

• order stem cell transplants manufactured by our company  for actual patient treatment,
  
  with worldwide delivery.

(Long distance consultation will soon be available via telemedicine link as well.)

Whenever you contact us on this web site in order to 

• get such a free advice via our online questionnaire, 

we will respond promptly.

Besides that we assign each prospective client an ID code, so that there is no need to use the patient's name in future communications, or on vials containing the patient's stem cell transplants. The combined effect of such steps is that sensitive medical data will not get into the wrong hands.