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What Is the Difference Between Implantation of Stem Cell Transplants of Human Versus Animal Origin 

Precursor stem cell transplants can be manufactured for clinical use from fetuses of any member of animal kingdom, from Homo Sapiens to fish. 

The frontal lobe of brain is the sole body part unique to man, and absent in all animals, so that when cells of the frontal lobe of brain would be necessary for stem cell transplantation, they would have to be procured from human fetus. (There is no clear indication for the use of frontal lobe neurons in stem cell transplantation yet.) 

All other stem cell transplants can be obtained from animal sources.

While there has always been a shortage of human organs, tissues and cells for transplantation, the cells, tissues and organs, of animal origin have been abundant. 

Stem cell xeno-transplantation can be used already today for treatment of thousands of sick people suffering from diseases that cannot be cured or even treated by any other therapy. They can be prepared in unlimited quantities, and ultimately at low cost.

Difficulties with procurement of human fetal material - ethical, moral, religious, psychological - that ultimately lead to paucity of such material for stem cell transplantation, have been, and will be, a continuous problem. 

It has been, and will be, hard to develop stem cell transplantation as a therapeutic method if there is enough material to treat only a few patients: this situation has been slowing down progress for many years. 

(biocell@stem-cell-transplantation.com)

Xeno-transplantation means the transplantation of live cells, tissues, or organs between the species, in our case from animals to humans, or reverse.

Allo-transplantation means a transplantation within species, i.e. from a man to a man, or from horse to a horse, etc.

Here are some scientific facts that explain why stem cell xeno-transplantation can be used instead of stem cell allo-transplantation. 

1. It has been known already since 19^th century, and the entire modern cell biology is based on the fact, that all eukaryotic cells in Nature are built and function according to the same laws. 
   
   In clinical practice of stem cell transplantation we have been dealing with eukaryotic cells (of mammals) only.
   
   
2. Main cells of the same organ or tissue are the same in Nature, (or nearly the same), regardless of the species of origin. 
   
   It means that corresponding cells of the identical organ of different animal species (including man) are biologically similar. The hepatocyte, the main cell of liver, is almost the same in all vertebrates, for example. 
   
   And we could make a similar statement about any of ~ 200 kinds of cells of human or animal body. Scientists call this a 'principle of organospecificity'.
   
   There are no antigenic differences between the corresponding cells of the identical organ of different animal species (including man).

   This is another proof of 'organospecificity'.

3. All biological systems in Nature are composed of the same types of molecules.

   Great majority of proteins from different organisms        (including man) is similar over the entire amino acid sequence, i.e. they are homologous of each other,

   and in general carry out similar functions.

   Scientists call this a 'principle of homology'.

   The homologous proteins evolved over billions of years from a common ancestor.

4. The basic law of molecular biology, whereby DNA directs the synthesis of RNA, that in turn directs the assembly of proteins, applies to all living beings. 
   
   Genetic encoding is the same in most known organisms.
   
   'Families' of similar genes encode proteins with similar functions. All that implies that life on Earth evolved only once.

The described scientific data explain why it has been possible to implant live stem cell transplants prepared from fetuses of sheep, cattle, pigs, horses, rabbits, and probably other mammals,

in ~ 5 million patients over the past 75+ years, without any fatality or other serious consequences for individual patients or mankind.

Our company has always manufactured stem cell transplants from rabbit fetuses (with the exception of stem cell transplants of various endocrine glands, where newborn rabbits have been the animal source; rabbitologists feel that there is no difference between a rabbit fetus after completion of organogenesis and a newborn rabbit). 

The above can be studied in a textbook of E. Michael Molnar, M.D. "Stem Cell Transplantation, a Textbook of Stem Cell Xeno-Transplantation", published by Medical And Engineering Publishers, Inc., Washington, D.C., in February  2006, the first textbook for medical profession and students in the world about this subject. Click on www.mepublishers.com

(biocell@stem-cell-transplantation.com)

Our know-how, based on 25+ years of experience, permits us to offer you in this web site  

• free advice about the usefulness of stem cell transplantation as a therapy of illness(es) that you, or your loved ones, suffer from, which you could get nowhere else on the Web, (click on "How to get SCT treatment" on the MENU bar, if you wish to learn more about this free service) 
  
  (Please, beware that stem cell transplantation is not a 'wonder' treatment for all diseases known to mankind, and so it may be of no use in your particular case.)

as well as a possibility to

• order stem cell transplants manufactured by our company  for actual patient treatment,
  
  with worldwide delivery.

(Long distance consultation will soon be available via telemedicine link as well.)

Whenever you contact us on this web site in order to 

• get such a free advice via our online questionnaire, 

we will respond promptly.

Besides that we assign each prospective client an ID code, so that there is no need to use the patient's name in future communications, or on vials containing the patient's stem cell transplants. The combined effect of such steps is that sensitive medical data will not get into the wrong hands.