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 Hormone deficiency disorders respond well to stem cell transplantation

 

Several hormone deficiency disorders, where hormone replacement therapy could not re-establish a normal hormonal balance, have been helped by stem cell transplantation (SCT) with increasing frequency (if you click on the above SCT link you will open our homepage where you learn more about this therapy and how to order our stem cell transplants)

(biocell@stem-cell-transplantation.com)

Besides diabetes mellitus there are other common hormonal diseases where the endocrine glands function is low, 

such as hypothyroidism, premature menopause, etc., 

in which stem cell transplantation may be necessary in patients who stopped responding properly to the standard hormone replacement therapy. 

Although some of these diseases, such as hypothyroidism, are as common as diabetes mellitus, the statistics of its incidence are not too accurate, 

because hypothyroidism is the cause of  death or seriously disabling complications only rarely, and its socio-economic significance is low.

It has been observed with increasing frequency nowadays that diseases with low function of endocrine glands respond to the hormone replacement therapy not as well as expected, even in hands of the best endocrinologist. 

At the same time physicians have been noticing more and more often that majority of patients diagnosed with hypothyroidism, or Addison disease (with low function of adrenal cortex), etc., developed such illnesses because of autoimmunity. 

This could explain a lower success rate of a classical hormone replacement therapy in such patients: 

  • the relentless progress of an autoimmune damage of hormone producing cells of the diseased endocrine gland ultimately leaves patient with very low quantity of functioning endocrine cells, 

  • so that even a high dosage of oral hormone pills cannot provide a patient with an adequate level of missing hormone,

  • but the competitive inhibition whereby the oral hormone therapy suppresses the function of patient’s own cells producing the same hormone may play a part.

In such instances endocrinologists have been turning to stem cell transplantation more and more often. 

The goal of stem cell transplantation in the treatment of such autoimmune diseases is 

  • mostly immunomodulation, e.g. normalization of immune system function, and thereby suppression of the autoimmune process, and 
     
  • a repair, or regeneration, of non-functioning hormone producing cells.
     

It is not a purpose of stem cell therapy to eliminate the need for hormone replacement therapy.

Stem cell transplantation should aim at balancing  regulations of the 'axis hypothalamus – pituitary - peripheral endocrine gland (thyroid in hypothyroidism)', disturbed by years of disharmony and demands for over-compensation.  

Level of hormones has to be measured after stem cell transplantation much more frequently, and the dosage of oral hormones lowered accordingly, but as a rule their intake cannot be discontinued.

If we disregard diabetes mellitus, among hormone deficiency disorders the most common indication for stem cell transplantation in clinical practice has been a pronounced hypothyroidism, which is practically always a result of Hashimoto’s (autoimmune) thyroiditis. 

Overall the numbers of patients with hypothyroidism so treated have not been high, and clinical reports have been but a few.

The treatment of hormonal diseases with low functioning sex glands is discussed elsewhere.

The use of stem cell transplantation as a treatment of endocrine diseases can be studied in a textbook of E. Michael Molnar, M.D. "Stem Cell Transplantation, a Textbook of Stem Cell Xeno-Transplantation", published by Medical And Engineering Publishers, Inc., Washington, D.C., in February 2006, the first textbook for medical profession and students in the world about this subject. Click on www.mepublishers.com

  (biocell@stem-cell-transplantation.com)

 

 

Our know-how, based on 25+ years of experience, permits us to offer you in this web site  

  • free advice about the usefulness of stem cell transplantation as a therapy of illness(es) that you, or your loved ones, suffer from, which you could get nowhere else on the Web, (click on "How to get SCT treatment" on the MENU bar, if you wish to learn more about this free service) 

    (Please, beware that stem cell transplantation is not a 'wonder' treatment for all diseases known to mankind, and so it may be of no use in your particular case.)

 

as well as a possibility to

  • order stem cell transplants manufactured by our company  for actual patient treatment,

    with worldwide delivery.

(Long distance consultation will soon be available via telemedicine link as well.)

Whenever you contact us on this web site in order to 

  • get such a free advice via our online questionnaire, 

we will respond promptly.

Besides that we assign each prospective client an ID code, so that there is no need to use the patient's name in future communications, or on vials containing the patient's stem cell transplants. The combined effect of such steps is that sensitive medical data will not get into the wrong hands.

 

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Updated: July 2005