STEM CELL TRANSPLANTATION

 

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 Immune Deficiencies and Autoimmune Diseases Respond Well to Stem Cell Therapy

Immune deficiency disorders, such as AIDS, chronic weakness syndrome, as well as cancer, and autoimmune diseases, have been a menace of modern medicine, because there has been 

  • not only no known cure, but also

     
  • no possibility to slow down the progress of such illnesses. 

During the last four years there has been a growing body of peer-reviewed publications reporting on the success of stem cell therapy (SCT) in the treatment of many cancers, both solid (such as cancer of colon, etc.), and dispersed (such as leukemias, etc.) (if you click on the above SCT link you will open our homepage where you learn more about this therapy and how to order our stem cell transplants)

So perhaps the scientific fact that stem cell transplantation is the most potent immuno-stimulant known to medicine today - by far - will no longer be one of the 'best kept secrets'. 

Immunological testing has been very crude and thus it is hard to assess the degree of benefit from the immuno-stimulating effect of stem cell transplants among those ~ 5 million patients treated by stem cell therapy over the last 70 years.

Modern medicine has a very limited armamentarium of therapies for immune deficiencies.  With the exception of stem cell transplants there are no effective direct immuno-stimulants available for treatment of diseases today.  

Stem cell transplantation stimulates immune system spectacularly well, particularly one that is weakened for one reason or another. 

And that applies to even such deadly diseases of immune system as AIDS, and cancer, in which the immune system has become debilitated as a result of an illness and a method of treatment used to combat it. 

It is therapeutically effective also against autoimmune diseases, apparently functioning as an immuno-modulator in a way that cannot be currently scientifically explained.

Since 1998 we have made our stem cell transplants available to 

  • physicians for treatment of their own patients, but also to

     
  • patients directly (naturally with physician's prescription),  

with worldwide delivery. 

This was a result of 25+ years' of research, GMP ('good manufacturing practice'),  and clinical experience with stem cell transplantation in patients suffering from various immune deficiency disorders and autoimmune disease.

  (biocell@stem-cell-transplantation.com)

The survival of a live organism without a defense against harmful factors of the inner and outer world, whether living or non-living, is impossible. 

The defense mechanism which has developed since the inception of life millions of years ago is a complicated and highly organized system which protects the biologic existence of every living being.

Contact with, and defense against, the environment are key properties of life. Intake and metabolism of life-sustaining matters are recognized as fundamental biological features, but the defense against damaging and life-threatening matters is on the same level of importance.

As sophisticated as the immune system is, it operates on a very simple basic principle. It distinguishes 'self' from 'non-self' and attacks 'non-self' with the ultimate goal of removing it from the body. 

Usually this works in our favor, such as when our body is attacked by pathogenic microbes. 

At other times it works against us, such as when our life depends on a transplanted organ: heart, liver or kidney, and our immune system attacks it as 'non-self' and causes its rejection.

One can think of the immune system as a defending army. This army consists of many different battalions, each battalion has to carry out a predetermined activity, and each soldier is ordered to handle a specific task. 

After all, this army has to fight off many kinds of invaders: bacteria, fungi, viruses, tumors, toxins, foreign proteins and every one requires a different battle plan. 

Without such army of immunological soldiers to fight them, operating according to the correct battle plan, we would succumb to the invaders before we would grow out of infancy.

The human immune system consists of three components:

  1. the epithelial surface, protecting us against outside world and the microbial world inside of our own bodies (there are more microbial cells in our body than of our own) - 

    this is historically (phylogenetically) the oldest part;

     
  2. the reticulo-histiocytary system, spread diffusely throughout our body - 

    this one had historically developed next;

     
  3. thymo-lymphatic system, consisting of 

    thymus gland, and
     
    network of lymphatic vessels carrying lymph, which is filtered in lymphatic nodes, and

     
  4. spleen, which filters blood, among other functions - 

    these two are the youngest part.

The lymphocytes are the most important cells of the defense system. More than a trillion of them are in the body at once, either circulating in the blood or on guard in the lymph nodes. There are two types of lymphocytes: T-cells and B-cells

Both are formed in bone marrow. B-cells mature in blood, while T-cells must pass through and mature in thymus gland. Thymus, located just behind the upper part of the breast bone, is like a drill sergeant, it instructs the lymphocytes how to recognize 'non-self' and what to do when 'non-self' invades the body.

T-cells are the sentries of our body. When the invader enters the body, T-cells sound an alarm and direct the battle. Through a complicated system they mobilize other lymphocytes and other 'soldiers', such as histiocytes, macrophages, etc., and 'weapons' (complement, cytokines, etc.) to fight the enemy. They also enter the battle directly.

B-cells produce plasma cells, which in turn produce antibodies. This system has a memory. Once a B-cell produced an antibody against a specific foreign antigen, it never forgets how to make it. 

Thus each succeeding wave of the same infection (or other type of antigen) is fought off with an increasing efficiency. This is the basis for immunization and also explains why we fall victim to several childhood infectious diseases only once.

Of course this 'immunological memory' works sometimes against us, too. 

When we are allergic to something - even though the object isn't, in itself, a threat - the body's immunological memory can unleash 'defensive' biochemical weapons and turn it into an illness ranging from sniffles to sudden death by suffocation (anaphylaxis).

Sometimes the immune system fails to recognize even parts of our own body as 'self' and attacks them as 'non-self'. 

This leads to 'autoimmune diseases', such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, glomerulonephritis, etc., against which there is no real treatment. 

The defense capabilities of our immune system have a 'life profile'. After 'immuno-tolerance' of the embryonic and fetal stage of life (when the immune system is not functioning and the entire defense depends on the immune system of pregnant mother and placenta), the immune system gradually 'wakes up', until it reaches the optimal functioning level between 10 and 15 years of age. 

During puberty the immune system function will become depressed again, the exact timing depends on the sex.

Afterward the immune system works at full capacity for the next 30 to 35 years. 

During the forties a regression period will inevitably ensue, when the function of immune system diminishes relentlessly until a senile 'immuno-paralysis' period is reached when body becomes defenseless against malignancy and even the most banal infections.

The use of stem cell transplantation as a treatment of immune and autoimmune diseases can be studied in a textbook of E. Michael Molnar, M.D. "Stem Cell Transplantation, a Textbook of Stem Cell Xeno-Transplantation", published by Medical And Engineering Publishers, Inc., Washington, D.C., in February 2006, the first textbook for medical profession and students in the world about this subject. Click on www.mepublishers.com

(biocell@stem-cell-transplantation.com)

 

 

Our know-how, based on 25+ years of experience, permits us to offer you in this web site  

  • free advice about the usefulness of stem cell transplantation as a therapy of illness(es) that you, or your loved ones, suffer from, which you could get nowhere else on the Web, (click on "How to get SCT treatment" on the MENU bar, if you wish to learn more about this free service) 

    (Please, beware that stem cell transplantation is not a 'wonder' treatment for all diseases known to mankind, and so it may be of no use in your particular case.)

 

as well as a possibility to

  • order stem cell transplants manufactured by our company  for actual patient treatment,

    with worldwide delivery.

(Long distance consultation will soon be available via telemedicine link as well.)

Whenever you contact us on this web site in order to 

  • get such a free advice via our online questionnaire, 

we will respond promptly.

Besides that we assign each prospective client an ID code, so that there is no need to use the patient's name in future communications, or on vials containing the patient's stem cell transplants. The combined effect of such steps is that sensitive medical data will not get into the wrong hands.

 

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Updated: August 2009