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Treatment of Aging Disease by BCRO Fetal Precursor  Cell Transplantation

  

"Aging has no known treatment“ has been a slogan perpetuated by drug regulatory agencies for decades. 

But 4 million (80%) out of 5 million patients treated by fetal precursor cell therapy  worldwide during the last 70 years have done so because they suffered from 'aging disease'. 

Their decision was based on their instincts and intuition , and in total disregard of official statements about a lack of acceptable research protocols to prove the value of any therapy in slowing down the aging process. 

Because the issue has always been 'not to add years to life, but life to years'.

One cannot treat aging related diseases, or for that matter many diseases in an aging individual, without anti-aging treatment.

On the other side one cannot seriously talk about the 'revitalization' or 'rejuvenation' therapies without a serious attempt to diagnose any and all diseases that the individual suffers from and their successful treatment: otherwise any attempt at 'revitalization' will fail! 

There is hardly a 40+ years old individual in the western world that is perfectly healthy physically, mentally and spiritually, and thus does not require treatment of 'aging disease'.  

(biocell@stem-cell-transplantation.com)

The Merck Manual of Geriatrics (1995) defines the 'usual aging' as 'changes due to the combined effects of the aging process and of disease and adverse environmental and lifestyle factors', while 'successful aging' as 'changes due solely to the aging process, uncomplicated by damage from environment, lifestyle, or disease'. 

This optimism about the possibility of 'successful aging' stems from the growing acceptance of the rights of the aging population to live a full and complete life rather than to die in a hurry right after the retirement in order not to be a burden on the society.

Only 30 years ago it was a taboo to talk in front of U.S. medical professional organizations about aging and particularly about its treatment. There were no National Institute of Health grants to fund any research on aging.

The situation was somewhat better in western European countries where one could come across serious medical publications on aging (Prof.Dr. A. Kment of Vienna, Austria, serves as one shining example).

World Health Organization organized a conference on aging in Helsinki, Finland, in 1993, that advised governments on problems in this area, and quite typically the conference did not devote any time to discuss how to influence aging by therapeutic means. 

The message to the aging population has been clear world over: governments have no money to keep aging population alive and well a day longer than necessary, so why to bother to talk about any therapies for the aging-related diseases…

The 'usual aging' should be classified as a disease, and all diseases related to aging should be clearly described as such. Scientists agree that genetically we are programmed to live 120 years. In reality we live on average only ~80 years (in civilized world). 

There are some societies with simple lifestyle where people live frequently much longer than that. 

But in western countries more and more people experience now a 'successful aging', too. As an example, aged people can achieve levels of oxygen consumption equal to those of sedentary young adults by a regular aerobic exercise.

The programmed aging process, which should lead to our graceful demise at the age of 120 years, is disrupted in principle by three factors:

  1. Severe illness,

  2. Severe trauma,

  3. Abnormal aging or 'aging disease'.

The first two factors are self-explanatory: severe disease or severe trauma can destroy even the healthiest individual. But what about the 'aging disease', ‘devitalization', biological age versus chronological age, ‘vitality’ as a measurement of ability of one’s organism to realize all vital functions in physical, mental, and spiritual spheres' ?

  • The rate of age-related decline in the function of every organ in the body varies greatly, so that people become less alike as they age. 

  • Within any individual the functions of different organs decline at different rates.

  • Each one of us has at least one weak organ or organ system (if not more than that).

  • Different people generally age at different rates.

There are two major types of 'aging diseases': 

  • there are aging mechanisms that are accidental or random, and 
  • there are those that are planned. 

Let’s explain this. When you buy a new car, in a few years that car will be worn out as a result of many little and larger accidents and improper care. 

But no matter how well you take care of your car, it will still age because a certain degree of aging has been 'built in' by the automakers, who made a decision not to build a car that will last more than 5 -10 years... 

Like our cars we seem to age 'by accident and by design': it is not only that the stresses and strains and traumas of everyday life set off processes which make us grow old, there is some internal mechanism which sets the limits to our life. 

We know a lot more about the accidental causes of aging than we do about the programmed 'aging clocks'.

"Mother Nature does not need us forever. Our evolutionary, biological purpose is fulfilled once we have produced offspring. Evolution, biology, or Mother Nature, is interested in only one thing: survival of species. And that means a continued production and survival of children. 

Once that is accomplished - once the children are old enough to take care of themselves - the parents are useless as far as Mother Nature is concerned. They have passed on their genes, and their survival skills, and have protected their young until they can protect themselves." (from "Forever Young 2")

It was not so long ago when our ancestors died in their mid-twenties. They fulfilled their duty of procreation and passed away. 

Are we required to live longer today for some reason? Are we perhaps in greater need of the wisdom and experience of older people to help ensure the survival of human race?

The 'alarm' on our 'aging clocks' seems to be set somewhere between ages of 35 and 40. Before that time our bodies have been in a state of dynamic equilibrium, constantly renewing, rebuilding, and replacing every cell in the body. 

Every seven years - by scientific estimate - nearly all molecules in the body are replaced by new molecules from the outside the body. 

"When the age alarm sounds, the replacement cells are not quite as good as the original. The homeostatic balance of growth, regeneration, and repair, versus trauma, destruction, and stress, begins to slip out of our favor." (from "Forever Young 2") 

"Our physiological functions begin to decline. Our ability to adapt to, and survive in a changing environment, declines.

  • All over the body, the structure of tissues becomes disorganized. 

  • More fat is deposited. 

  • Active tissue is hidden or lost. 

  • Individual cells increase in size, but decrease in number, by almost one-third. 

  • Connective tissue between cells, muscle fibers, and bones increases and becomes less elastic.

The heart muscle and the valves of the heart lose more and more of their elasticity and strength, although the left ventricular wall thickens as a result of increased size of muscle cells and increased amount of fibrous tissue. 

As the heart grows weaker, the blood vessels become more rigid due to changes in the amount and nature of elastin and collagen in their walls, and calcium deposits, and clogged with fatty deposits of atherosclerosis. Blood pressure rises.

In the kidneys, the number of working nephrons decreases 30 - 40 percent between ages 25 and 85, with the related loss of renal mass, particularly of the cortical layer. This leads to a reduced renal blood flow, glomerular filtration rate and performance of tubular system.

The vital capacity of the lungs decreases, while the residual volume increases. The gas distribution irregularities and decreased compliance of the lungs cause a lowering of arterial oxygen tension. 

The diameter of chest wall increases, but the flexibility decreases. The maximum breathing capacity decreases steadily: in 80s it is one half as compared with 30s. From age of 55 on the respiratory muscles begin to weaken.

Of all functions of the digestive system the motility is affected by aging process first of all. This leads to constipation, incontinence and diverticulosis, which become a cause of many problems with digestion and absorption of nutrients. Production of digestive juices, with all the enzymes, declines. 

Liver weight and its blood flow decrease.

The skin wrinkles, sags, and grows less and less elastic and drier. Healing takes longer. The hair thins and turns gray. Nail growth slows down.

Loss of muscle cells and disorganization of muscle tissue cause a progressive reduction in muscle strength. Half of muscle mass and of maximum isometric contraction force is lost between ages of 30 and 75. Joints deteriorate. Bones become weaker as more minerals are lost than are replaced.

Blood flow to the brain is reduced. Lost nerve cells are mostly not replaced. Connections between nerve cells are substantially diminished.

Vision deteriorates as the lens and other parts of the eye become less transparent. Vision dims as well as a result of decreased adaptation to low light and dark. Senses of taste, touch, smell and hearing grow weaker.

Menopause appears in women, loss of sexual potency in men.

Psychometrically, reaction time slows down, learning takes longer, memory fades, in particular the recent one. The social skills and intellectual abilities of young years begin to slip away. There are changes of personality. The gross motor and fine motor abilities and coordination deteriorate." (from "Forever Young 2")

When it comes to the treatment of 'aging disease' the opinions vary. This is due to the lack of a single hypothesis capable to possibly explain all of the aging processes. According to the Merck Manual of Geriatrics (1995) there are six such theories. Experts of fetal precursor cell therapy have always believed in a complex approach consisting of various biological therapies, but fetal precursor cell transplantation is the most important.

The use of fetal precursor stem cell transplantation as a treatment of aging disease can be studied in a textbook of E. Michael Molnar, M.D. "Stem Cell Transplantation, a Textbook of Stem Cell Xeno-Transplantation", published by Medical And Engineering Publishers, Inc., Washington, D.C., in February 2006, the first textbook for medical profession and students in the world about this subject. Click on www.mepublishers.com On the same web site you can can find the latest book by the same author: 'Treatment of Incurable and Untreatable Diseases', published for general readership by the same publisher in November 2012.

  (biocell@stem-cell-transplantation.com)

 

 

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Updated: April 2014